A non-alcohol-related fatty liver disease affects about a quarter of the adult population worldwide. Obesity, insulin resistance, lipid metabolism disorders, as well as changes in the intestinal flora, are among the causes. However, the innovation underlying mechanisms are still unclear. Now researchers have discovered a new clue, what could cause the damage: they have found more than 60 percent of those Affected, certain strains of bacteria in the gut, the large amounts of alcohol produce.
"We were surprised that the bacteria produce as much alcohol können", Jing Yuan by the municipal Institute of Pediatrics in Beijing said. "When the body is overloaded and can not be degraded by these bacteria produced alcohol, not a fatty liver disease, even if you drink."
Yuan and colleagues came to the idea that there could be between the intestinal bacteria and non-alcoholic fatty liver is a connection, as you are a patient with severe liver damage and the rare "Self-Brauer-Syndrom" met. These patients have microorganisms in the intestine after the consumption of alcohol-free, sugar-rich foods so large quantities of alcohol to produce that they become drunk or symptoms of poisoning get.
Normally there are yeasts that cause, but in this patient, no were in the game. Instead, the researchers found several strains of Klebsiella pneumoniae – actually, normal intestinal bacteria – the generated in this patient, four to six times more alcohol than strains that occur in healthy people.
As a result, the research team studied these bacteria in patients with non-alcoholic fatty liver and Healthy and found that about 60 percent of the Patients had such strains in the gut, but only six percent of the Healthy. By Transmission of these strains to mice, scientists were able to cause fatty liver disease even in the animals: This developed after two months, liver damage, similar to those that occur when mice are fed with alcohol. An antibiotic abtötete the Klebsiella, improved their condition.